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Description

Tirzepatide is FDA-approved for weight loss under the brand name Zepbound and is available in Canada through Mounjaro (approved for type 2 diabetes) with growing off-label weight management use

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Diabetologia 2023;66(10):17651779

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44 The zinc wave originates in the perinuclear region, including the ER, and depends on calcium influx and MEK activation

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Patients should understand that GLP-1 receptor agonists are not contraindicated in liver disease and may actually provide hepatic benefits

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The dose response extends beyond weight loss to metabolic parameters

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