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But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

Mechanical ventilation may be necessary in patients who require airway protection or who develop cerebral oedema or respiratory depression

Gao SS, Li DY, Huo ZK, Zhang YL, Cao YZ, Tan YY, et al

Bone morphogenetic protein 2 and decorin expression in old fracture fragments and surrounding tissues

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