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Finally, the platform is designed to evolve

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Consider avoiding things that increase (i.e., induce) CYP1b1 and CYP3a4 enzymatic activity Recall that CYP1b1 is the enzyme that converts estrogen to the 4-OH metabolites and CYP3a4 is the enzyme that converts estrone (E1) to the 16-OH-E1 metabolite, and estradiol (E2) to estriol (E3)

Regardless of which route you choose, success ultimately comes down to consistency, realistic expectations, and staying motivated throughout the process

And reductions in reactive oxygen and nitrogen species pointed to a meaningful decrease in neuroinflammatory burden, one of the central drivers of progressive neuronal injury in Alzheimer's disease