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Topical serums work at the skin surface and in the uppermost layers of the dermis, which means they address pigmentation locally rather than systemically

In clinical practice, the degree of weight loss with lifestyle intervention is only moderate, and the success rate 2 years after onset of an intervention is low ( 40% reached a category below the obesity threshold [14]

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Rapid changes in blood pressure or heart rate

The benefits of GLP-1 RAs extend to a variety of nonglycemic clinical effects [19] (Fig