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SLD is a chronic liver condition caused by alcohol overconsumption and metabolic disturbances such as obesity and insulin resistance, leading to fat accumulation in the liver, inflammation, and eventually fibrosis

Even though this phenomenon has not been fully understood in the context of the possible exacerbation of pro-depressive changes by GLP-1RA administration, it certainly requires careful investigation before the potential introduction of these compounds to the clinic for the treatment of mood disorders in the future

This manifests in two ways

In the liver, although both increased FFA uptake and upregulated de novo lipogenesis contribute to the development of hepatic steatosis, accumulating evidence suggests that increased FFA uptake plays a predominant role in the development of fatty livers 1

doi: 10.1038/s41586-019-1705-2 98 DollSFreitasFPShahRAldrovandiMDa SilvaMCIngoldIet al