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4 Although some literature states that it may be used as first-line therapy, tramadol lacks FDA approval and is recommended as an alternative to duloxetine, milnacipran, or pregabalin

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Another study, not yet published, is SURMOUNT-OSA, a clinical trial of 52-weeks that examined the efficacy and safety of TZP versus placebo in obese participants and an established OSA diagnosis for treatment of moderate and severe OSA (102)

[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Bruner-Tran K.L., Osteen K.G., Taylor H.S., Sokalska A., Haines K., Duleba A.J

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