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Muscle fills some of the volume that fat previously occupied, creating a more taut surface for the skin to drape over

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Yes, but it depends almost entirely on what you built during the protocol

In a recently published review, the advantages of eryptosis over hemolysis as a toxicological endpoint have been summarized, emphasizing that eryptosis in vitro testing has a higher sensitivity, is more accurate and reproducible, provides better quality control, and can shed light on the cytotoxicity-mediating molecular mechanisms compared with hemolysis [450]