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The application of these principles, however, may not always be as clear-cut as desiredparticularly in the case of a rare disease where there are unavoidable limits on our scientific knowledge

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When a single dose (0.2 mg/kg) daily for 3 days (0.3 mg/kg) of PQQ was administered to 10 young participants (five males and five females), the levels of trimethylamine N-oxide, a marker of perturbed energy metabolism, decreased following PQQ intake

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There is still no point pretending this is a miracle cure