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Epub 2015 Oct 21

The finished compounded product is not reviewed or approved by the FDA

Author contributions MP, MM, and DP-S designed the study, performed experiments, analyzed data, prepared figures, and wrote the manuscript

Rutin is a flavonoid found in various plants, has been reported to ameliorate DN by lowering plasma glucose levels and decreasing OS via the Nrf2 signaling pathway (Tian et al., 2016)

Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below