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Data Availability All data generated or analysed during this study are included in this published article/as supplementary information files

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Common Side Effects Experienced by some users Headache Mild to moderate headaches are commonly reported, likely related to increased neural growth factor signaling and cerebral blood flow changes associated with HGF/c-Met activation

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To increase the plasma half-life, a slower-releasing formula of exenatide was developed by incorporating to a polymer microsphere, permitting a once-weekly injection

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slower dose titration and dietary modifications can reduce severity and duration

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The pregnancies caused abdominal muscle separation (rectus divarication) with core muscle weakness

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