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Mutations in these loops can occur at key positions that lead to loss of function

Even though different RCDs are considered individual and independent cell death modes for classification purposes, interconnectivity and extensive crosstalk on the basis of the shared molecular signaling network, redundancy, feedback, and backup function are well documented [10]

Two of these pathways involve the addition of highly water-soluble structures: glucuronate via the glucuronide pathway or sulfate via the sulfation pathway

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Immunofluorescence staining showed correct ER localization for all constructs, with high overlap with calreticulin, an endogenous ER marker (Fig