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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression

The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on substance use disorder (SUD)-related behavioural effects of drugs and alcohol: a systematic review

Medicare does not cover FDA-approved weight-management drugs for weight alone as of April 2026, though some products carry cardiovascular-indication coverage

What the Research Shows About GLP-1 Weight Loss Medications Clinical studies on GLP-1 receptor agonists have shown promising results for individuals with obesity or weight-related health concerns

Obesity Research A phase 2 randomized trial published in NEJM included 338 adults