Some studies show small effects on appetite, mood, or metabolic values, but significant and reliable weight loss has not yet been proven
Digestive symptoms: Mild nausea, burping, bloating, or constipation may appear and usually improve gradually
SPOTLIGHT The astounding rise of semaglutide and whats next for weight-loss drugs Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access $199.00 per year only $3.83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout doi: This article is part of Nature Spotlight: Obesity, an editorially independent supplement
Whilst most digestive side effects are mild to moderate and self-limiting, there have been very rare post-marketing reports of more serious gastrointestinal complications, including gastroparesis (severe delayed gastric emptying) and intestinal obstruction, though causality has not been established
Summary-level GWAS statistics for AD were obtained from the publicly available meta-analysis by Bellenguez et al
