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This finding was further validated in the ID8-luc-P53 -/- mouse model, where the combination therapy group exhibited the lowest proportion of senescent CD8 T cells in the spleen, ascites, and IDLNs (inguinal draining lymph nodes) compared with other groups, along with the highest levels of CD8 T cell effector functional molecules GZMB, FASL, and IFN- in ascites, as well as IL-2 levels in CD4 T cells (Fig

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