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In its announcement, which came Friday afternoon, the FDA noted that safety and efficacy of Wegovy in the new indication were based on a trial comprising 17,600 patients randomized to receive either Novos drug or placebo, as well as standard medical treatment and lifestyle counseling

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(101) found that in Hodgkin lymphoma cell lines, the proteasome inhibitor Ixazomib (2575 nM) transiently inhibits proteasome activity, but subsequent functional recovery occurs due to NFE2L2 (NRF2)-dependent upregulation of proteasome gene expression

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