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Comparisons were measured by calculating any differences in HbA1c, blood glucose control, body weight and risk of adverse events

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To achieve cell-type specific knockdown, we prepared a mixture of adeno-associated virus (AAV)-GFAP104-Cre-mCherry virus with either Lenti-pSico-scrambled-EGFP (control) or Lenti-pSico-MAOB - shRNA-EGFP (MAOB KD)