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it blocks opioid receptors and, when paired with bupropion, may potentiate appetite suppression through the pro-opiomelanocortin (POMC) system in the hypothalamus (a mechanism similar to the FDA-approved bupropion/naltrexone therapy)

Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children

They work by mimicking two natural hormones in the bodyGLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide)which help to regulate blood sugar, reduce appetite, and improve feelings of fullness

[DOI] [PubMed] [Google Scholar] 50.Watanabe T., Hoshi K., Zhang C., Ishida Y., Sakata I

Mol Metab 81:101895 Mirabella PN, Fenselau H (2023) Advanced neurobiological tools to interrogate metabolism