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Clin Genet 2020;97:586-94

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Results The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue

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Tirzepatide, the first dual GIP/GLP-1 agonist, received US Food and Drug Administration (FDA) approval in 2023 (Zepbound ) after demonstrating superior efficacy over semaglutide, including 22% weight loss and enhanced glycaemic control [7678]