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Participants given Amarasate or placebo at hours 16 and 20 were evaluated for hunger and satiety with a standard visual analog scale (VAS) every 30 minutes after capsule administration

These include: Enhanced glucose-dependent insulin secretion Suppressed glucagon secretion Slowed gastric emptying Increased satiety via central hypothalamic action This results in both glycaemic improvement and clinically meaningful weight loss

En pacientes previamente tratados con metformina y/o sulfonilureas la adicin de por lo menos 3 aos con GLP1-RA, evidencindose una mejora de marcadores lipdicos como triacilglicridos (-12%), colesterol total (-5%), LDL (-6%) y HDL (+24%) 149

GHK-Cu: Added for its extracellular matrix rebuilding properties

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