By the end of the 7day treatment, the plasma carnitine concentration had reached a median of 45 M (IQR: 36.850.6), corresponding to an increase of 22% over the baseline value
Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015
Stay hydrated to help cellular metabolism function efficiently
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In this study, a high concentration cholesterol-induced lipotoxicity was observed in INS-1 cells, including inhibited cell viability and insulin secretion