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A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating

Secondary and sensitivity analyses In our secondary analyses, we did not observe evidence of effect measure modification by individual drug, age, sex, body mass index, history of suicidal ideation, history of depression, or socioeconomic status, as indicated by overlapping 95% confidence intervals in all comparisons (supplementary tables S4-S7)

Bakri has just released a new app which is focused on circadian biology, which we didn't talk about today, but he's a true expert there as well

Hydrating with water or electrolyte-rich beverages restores balance so the body continues cleansing efficiently

Gallbladder disease & gallstones often leading to emergency surgery