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However, some patients receiving high-dose B12 supplementation or injections may experience adverse reactions, though these relate to the treatment rather than the elevated levels: Possible reactions to B12 supplementation (particularly injections): Skin reactions, including acneiform eruptions or rashes Pruritus (itching) Injection site reactions (with parenteral administration) Rare hypersensitivity reactions Non-specific symptoms such as headaches, dizziness, or gastrointestinal disturbances have been reported by some patients taking B12 supplements, but causality is not well established in clinical evidence

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KN content was significantly suppressed in Rib + amlodipine (31%), Rib + aminoguanidine (25%), and Rib + NAC (15%) compared to Rib

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[DOI] [PubMed] [Google Scholar] 51.Wood J.L