Rapid weight loss can signal energy deficiency to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) secretion
J Endocrinol 219:5968 Gaudin-Audrain C, Irwin N, Mansur S, Flatt PR, Thorens B, Basle M, Chappard D, Mabilleau G (2013) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to modifications of trabecular bone volume and quality in mice
GLP-1 RAs administered included semaglutide (48 patients), dulaglutide (13), and liraglutide (5), with a median follow-up of 18.5 months
Regular follow-up appointments allow providers to assess the effectiveness of treatment adjustments and track any further developments
Instead, focusing on a single medication, along with lifestyle modifications and complementary approaches, can yield the best results for managing weight and blood sugar levels