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requires medical knowledge to minimize risk Intranasal Intranasal delivery to target the olfactory bulb and trans-cribriform access to the brain has been explored for some peptides: Theoretical advantage: Direct CNS access, bypassing the blood-brain barrier Reality: Intranasal peptide formulations are complex and Dihexa is not commonly available in this form Evidence: No published data on intranasal Dihexa efficacy or safety Oral Bioavailability: Approximately 38% The most commonly cited bioavailability figure for oral Dihexa is approximately 38%
Weeks 9-16: reaching therapeutic doses The jump from 0.5 mg to 1.0 mg is the largest percentage increase in the titration schedule, doubling the dose
Association vs
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