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Retatrutide Side Effects The Phase 2 retatrutide trial (Jastreboff et al., NEJM 2023) reported gastrointestinal adverse events as the dominant side-effect pattern, consistent with other GLP-1-class drugs

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The symptoms resemble those of a physical bowel obstruction, including bloating and constipation, and the condition can lead to dehydration

Safety first: If you're pregnant, breastfeeding, on blood thinners or chemotherapy, or managing a chronic condition, speak with your doctor before starting any new supplement including this one