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In addition, each complex displayed transient van der Waals interactions between the G H4 and S6 domains and ICL3/TM6 of the receptor, that were, for the most part, not observed in the GLP-1 bound complex, albeit that specific interactions also differed between the individual peptide complexes (Figure 8B, Supplemental Figure 13, Supplemental Table 4)

One possible explanation for these differences is that GLP-1Rs expressed in neurons across various brain areas may have varying affinities for specific GLP-1R agonists

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Acknowledgements The present review was supported by grant no