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Pain Res Manag 2021:5529741

Histopathologically, naevomelanocytic naevi are characterised by several directly contacting naevomelanocytes in clusters confined to the junction of the epithelium and the lamina propria (junctional naevi), to both junctional zone and to the superficial lamina propria (compound naevi), or only to the subepithelial connective tissue (intra-lamina proprial naevi)

Simply put, it works by activating specific melanocortin receptors in the central nervous systemthe brain

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The lipoproteins of each pool of plasma were isolated sequentially by differential ultracentrifugation at 110 000 g at 20C in a Beckman rotor 60-Ti