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However, in hemorrhagic post-stroke epilepsy and PTE, large amounts of Fe 2+ from red blood cells and hemoglobin are released into the brain, and these Fe 2+ ions may be involved in inducing ferroptosis ( FIGURE 2 Regulation of Ferroptosis by Cysteine-Glutathione (Cys-GSH) Redox Axis Previous studies have shown that oxidative stress causes ferroptosis (Xiao and Meierhofer, 2019)

Supplementary Table 2a)

Similarly, polydatin, an inhibitor of glucose-6-phosphate dehydrogenase (G6PDH), was expected to impair NADPH regeneration, thereby limiting glutathione recycling

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Moreover, it has been systematically demonstrated that OSA improves significantly with weight loss [1114]