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Rapid dose increases can cause severe side effects

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Patients who used Zepbound for 36 weeks lost an average of 21%, but then, when switched to a placebo, after 1 year, they had regained 14% of their weight back

These may include: Feeling sick (nausea) Tummy pain Diarrhoea or constipation Headache Rare but serious side effects: Inflammation of the pancreas (very bad tummy pain, which travels to your back) Gallbladder problems Allergic reactions Always tell your doctor if you feel unwell while taking these medicines

the intent of the hindered insertion moiety is that it remains non-functional until the TF construct localizes within the tumor environment, and allows the hydrophobic appendage to become accessible and even further promote physical association with the membrane