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Neurological Changes : Numbness, tingling, and weakness in hands and feet from nerve damage

The amino acid sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) includes an unusual triple proline structure conferring exceptional stability

Epidemiology Incidence affects ~0.2% of Caucasian population Demographics 4:1 male:female usually presents in 3rd decade of life Etiology Pathoanatomy exact mechanism is unknown, but most likely due to an autoimmune reaction to an environmental pathogen in a genetically susceptible individual