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Without treatment, hyperthyroidism can progress to a thyroid storm (thyrotoxicosis)a potentially fatal condition characterized by high fevers, abnormally fast heart rate, nausea, vomiting, shakiness, agitation, and psychosis

It was originally developed as a synthetic dye, but its medical and scientific applications were discovered quickly

Expanded major adverse cardiovascular events (MACE) were defined as a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and hospitalization for heart failure

doi:10.1007/s40675-017-0071-6

The synthesis, secretion, and metabolism of numerous hormones, particularly adrenal hormones, depend heavily on zinc