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Wang J, Li S, Xu H, Xue J, Wan X, Wu W, et al

Aliment Pharmacol 55(8):944959

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4-6% placebo Diarrhea: 12-17% Vomiting: 5-10% Constipation: 6-11% Decreased appetite: 5-11% GI events are predominantly mild-moderate and occur mainly during dose escalation (first 4-8 weeks), with significant attenuation over time Serious adverse events of interest : Pancreatitis : Adjudicated pancreatitis events occurred at rates of approximately 0.1-0.2% across the SURPASS program, comparable to rates seen with GLP-1 agonists

Sp1 regulates basal NOS3 expression and responds to stimuli like growth factors and hypoxia, enhancing NO production to maintain vascular tone (Tang et al., 1995