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Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas

iScience 24 , 116 (2021)

Acknowledgements ICR BSU and Imperial College London CBS for supporting the in vivo study

FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

However, unnecessary supplementation offers no added benefit if your B12 levels are already normal