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While both GLP 1 & GIP therapy and GLP 1s are GLP-1 receptor agonists that help with weight loss, GLP 1 & GIP therapy also includes a second mechanismGIP receptor activationwhich enhances its effectiveness

S1PR2, sphingosine-1-phosphate receptor 2

However, the story is nuancedthe failure of the EVOKE trials testing oral Semaglutide in symptomatic Alzheimers Disease does not invalidate the strong epidemiological signal for GLP-1 agonists in dementia prevention, and SS-31s approval establishes important regulatory precedent for mitochondrial-targeted therapeutics

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