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They also stimulate insulin secretion in pancreatic -cells, but their effects on glucagon production in pancreatic -cells differ, with GIP having a glucagonotropic effect during hypoglycemia and GLP-1 exhibiting glucagonostatic effect during hyperglycemia
Cusi K, Sattar N, Garca-Prez L, Pavo I, Yu M, Robertson KE, et al
Safety Profile Well-Tolerated : Semaglutide is generally well-tolerated, with common side effects being gastrointestinal, such as nausea and vomiting, which typically decrease over time
GI, Gastrointestinal
TNF- inhibitors such as Infliximab and Etanercept did not show benefits in chronic heart failure due to the worsening of the clinical status and some serious adverse effects, such as upper respiratory tract infections [18, 19]
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