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Clinical trials have shown that Saxenda can lead to significant weight loss when used in conjunction with a reduced-calorie diet and increased physical activity

Per Humana's pharmacy policy (effective 1/20/2025), coverage requires ALL of the following: [4] Moderate-to-severe OSA diagnosis (AHI 15 on polysomnogram or REI 15 on home sleep test) BMI 27 kg/m (lower threshold than FDA label's obesity requirement) Using Zepbound with lifestyle modifications (reduced-calorie diet + physical activity) NO diabetes diagnosis (type 1 or type 2)this is an exclusion criterion Use diagnosis code G47.33 for OSA as the primary diagnosis, with obesity as secondary

[6] These agents were initially developed for type 2 diabetes management but have demonstrated significant efficacy in weight reduction, leading to their expanded use in obesity treatment

Safety Profiles Side by Side Gastrointestinal Adverse Events | Event | Tirzepatide 15 mg (SURMOUNT-1) | Retatrutide 12 mg (Phase 2) | |---|---|---| | Nausea | 31% | 47% | | Vomiting | 16% | 25% | | Diarrhea | 22% | 17% | | Constipation | 19% | 13% | | Discontinuation due to GI AEs | 4.3% | 16.6% | Discontinuation rates in the retatrutide phase 2 trial were substantially higher than those seen in tirzepatide's phase 3 program, which may reflect a steeper titration schedule, the additional glucagon receptor burden, or the smaller trial population amplifying extreme responders [2][3]

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