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Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts

Kumari S, Rai N, Singh S, Saha P, Bisen MS, Pandey-Rai S (2024) Heterologous expression of AaLac1 gene in hairy roots and its role in secondary metabolism under PEG-induced osmotic stress condition in Artemisia annua L

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This physiological barrier is composed of specialized endothelial cells that line the blood vessels in the brain, tightly regulating the passage of substances between the bloodstream and the brain tissue [5]