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In early 2026, Roche paid $100 million to secure a non-exclusive patent licence from Structures subsidiary Gasherbrum Bio, covering intellectual property relevant to CT-996, the oral GLP-1 compound Roche acquired through its $2.7 billion buyout of Carmot Therapeutics in late 2023

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Compound 47 exhibited the best IRAP inhibitory capacity (IC50 = 105 nM) and demonstrated an almost 10-fold selectivity vs

Deficiency in insulin leads to elevated levels of free fatty acids in the plasma as a result of uncontrolled lipolysis in adipose tissue

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