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Viral or microbial DNA facilitates gp78 interaction with INSIG-1 and stimulator of interferon genes (STING), resulting in K27-linked polyubiquitination of STING, a noncanonical ubiquitin chain topology of ubiquitin that serves as an anchoring platform to recruit TANK-binding kinase 1 (TBK1) and facilitate its translocation to perinuclear microsomes, resulting in the innate immune response

This effect was present but weaker at 2.5mg

PMID: 6877358

Close monitoring of kidney function during dose escalation is important

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