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In diet-induced obese and genetically obese/diabetic mouse models, this molecule showed stronger effects than GLP-1GIP co-agonism, semaglutide, or lanifibranor alone in reducing body weight, food intake, and hyperglycaemia

Looking at individual single nucleotide polymorphisms (reviewed in [181]), the PNPLA3 rs738409 G-allele has been best studied as a modifier for the dietary response

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These results were also relatively proportional to the inhibition of murine tyrosinase enzyme activity as predicted from the cell-free tyrosinase inhibition assay (Fig