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Results IKE inhibits the xCT transporter activity and decreases the viability of HCT-116 cells SRB test was performed to determine the effect of xCT transporter inhibitor IKE on cell viability in the concentration range of 10-4000 nM, which targets glutathione inhibition applied for 48 h in HCT-116 CRC cells

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This trend persisted in taf12L/ mutant backgrounds, where both Taf12L and Taf12 showed poor TET -driven expression (Figure S2A)