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EGFR and c-MET have in common similar downstream pathways: MAPK (RAS/Rapidly accelerating fibrosarcoma (RAF)/ MAP kinase kinases (MEK)/ERK) and PI3K/AKT/mechanistic target of rapamycin (mTOR)

Women in perimenopause experience menstrual irregularity and may have hot flashes, sleep difficulty, depressed mood or anxiety, and vaginal dryness, especially in late perimenopause

Anemia, which results from a shortage of red blood cells, is a common source of physical exhaustion

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