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Combine them with lifestyle interventions like meeting with a dietitian, eating less processed foods, and finding ways to be more physically active. People who use GLP-1s without lifestyle changes may gain weight back after stopping the medication

As of early 2025, retatrutide remains an investigational medication that has not yet received approval from the MHRA (Medicines and Healthcare products Regulatory Agency) or other major regulatory bodies

Araj-Khodaei, M., Ayati, M

The starting dose in patients already treated with metformin should provide sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of metformin already being taken

Non-financial interests: ZM, SG, MP, and AM were Nestle Nutrition Institute Fellows