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However, excessive exercise and overtraining can have adverse effects, so it's important to follow a balanced exercise program

In initial animal studies, that elucidated the role of glucose metabolism in insulin secretion, the rodent GLUT2 transporter was identified as the major sensor and transporter of glucose in pancreatic -cells

Cell death was correlated with expression of genes associated with the apoptotic cascade, such as caspase-3 and BCl2, and was prevented by pretreatment with an L-type voltage-gated channel blocker, thus confirming the classic excessive calcium-induced excitotoxic pathway of cell death (153, 154)

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