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Ideally, like the anti-GIP antibody in MariTide, it not only offers structural protection but also exhibits biological activity

Comprehending this mechanism provides insight into the origin of these symptoms

A cohort study revealed an increased risk of pancreatitis, and 36% of patients who used GLP-1 RAs or DPP- 4 inhibitors had elevated serum amylase or lipase (or both) levels compared with 18% of patients not taking these agents ( Our studies showed GLP-1 RA-associated gastrointestinal toxicities occurred 30 days (3,234, 77.44%) after the initiation of GLP-1RAs, and the median time-to-onset was 1 (IQR 024) days with a significant difference between different GLP-1 RA regimens

doi: 10.21873/anticanres.14136

However, its increasing off-label use for rapid weight loss has brought attention to its unintended effects on facial esthetics and skin health