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But it is inaccurate to interpret STEP-1 and SURMOUNT-4 as evidence that weight regain is inevitable after GLP-1 discontinuation

Patients who lose 23 pounds in month one often lose 1020 pounds by month three

The medication works on GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1 is reduced in the adipose tissue of morbidly obese subjects

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