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Injecting too quickly, using cold medication straight from the refrigerator, or repeatedly injecting into the same spot all increase the likelihood of nodule formation

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Furthermore, signal transducer and activator of transcription 3 (STAT3) can inhibit the mTOR/HIF-1 pathway by activating AMP-activated protein kinase (AMPK), leading to reduced cell proliferation and increased apoptosis (38)

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