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GLP-1 is able to stimulate cAMP formation in RIN 1046-38 cells, which in turn causes an increase in insulin mRNA levels and insulin release, and insulin accumulation in the culture fluid was observed by adding GLP-1 (7-37) to RIN 1046-38 cells for 1 h incubation (Mojsov et al., 1987)

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Those are precisely the questions the larger, longer Phase 3 TRIUMPH program is designed to answer, which is why an approval decision waits on it

Across the STEP program, cholelithiasis (gallstones) occurred in roughly 13% of semaglutide-treated participants versus less than 1% on placebo