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This fixed-ratio combination leverages complementary mechanisms of action to produce superior metabolic effects compared to either agent alone [7] : The CagriSema combination demonstrates that dual targeting of amylin and GLP-1 receptors produces additive or synergistic effects, representing a promising avenue for advanced metabolic research [7]

1) TGF-/SmadHDAC3 axis: HDAC3 [regulated by TGF-/Smad (107)] promotes fibrosis

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