Compared with the prior art, the invention has the following advantages: (1) The sequence of the coupling reaction is controlled, namely a main peptide chain is coupled with a side chain with a tertiary butyl protection on a carboxyl, then coupled with Boc-His (Trt) -Aib-OH dipeptide, and finally two protecting groups of Boc and t-Bu are simultaneously removed by a one-step method, so that the semaglutide with the purity of more than or equal to 97 percent can be obtained by only 3 steps in the whole process
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How do Peptides Help to Fight Aging
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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.ACG clinical guideline: epidemiology, risk factors, patterns of presentation, diagnosis, and management of colon ischemia (CI) Brandt LJ, Feuerstadt P, Longstreth GF, Boley SJ
